When Your Legs Are Crying for Help: 5 Important Things to Watch For

that something is not right. On its own, this symptom is not specific to liver disease, but in combination with tiredness, abdominal swelling, jaundice, or appetite changes, it becomes more important to evaluate.

2. Pain or discomfort in the upper right abdomen

The liver sits in the upper right side of the abdomen, and some liver conditions can cause pain, pressure, or discomfort in that area. This does not happen in every case, but when it does, it should not be ignored, especially if it appears with other symptoms on